Many sporadic and Mendelian disorders are caused by exonic mutations that alter the amino acid sequence of the affected gene. Exome sequencing has so far shown great utilty in elucidating single nucleotide mutations that contribute to these diseases. However, using exome sequencing to detect rare copy number … See more We would like to thank the FORGE Canada Consortium for allowing us to use exome data to test the algorithm and Kevin Ha for … See more We believe that looking for rare CNVs in exome-sequencing data can be a powerful way of detecting new disease-causing mutations. Until now, efforts on this front have been largely limited by the computational tools … See more WebSUMMARY: Rare copy number variations (CNVs) are frequent causes of genetic diseases. We developed a graphical software package based on a novel approach that can …
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WebFishingCNV_1.5.2 (2013-07-10): - Fixed some rounding errors -- some integer divisions were changed to floating point divisions FishingCNV_1.5.2: - Multiple file selections are … WebJan 4, 2016 · To verify variants identified by FishingCNV, and to validate their intragenic breakpoints, whole genome libraries were generated and sequenced. Approximately 1 μg of DNA was sheared into 200–300-bp fragments using a Covaris S2, and an Illumina-compatible sequencing library generated using NEBNext® Ultra™ reagents (New … imc martial arts
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WebMar 28, 2013 · Europe PMC is an archive of life sciences journal literature. WebA graphical software package based on a novel approach that can consistently identify CNVs of all types from exome-sequencing data without the need of a paired control is developed. SUMMARY Rare copy number variations (CNVs) are frequent causes of genetic diseases. We developed a graphical software package based on a novel approach that … WebFeb 25, 2024 · because FishingCNV occasionally breaks a CNV into smaller segments, particularly for larger CNVs. Data were also manu-ally reviewed to identify CNVs that were broken into smaller segments and therefore removed by the above filter. CnV analysis in replication cohort Raw intensity data were obtained from 1390 subjects using the imc mass cytometry