Cisplatin apoptosis induction

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August undefined, 2024

WebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts … WebApr 7, 2016 · Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction Metformin, one of the most common prescriptions for patients with type 2 diabetes, is reported to protect the kidney from gentamicin-induced nephrotoxicity.

Effective treatment of drug-resistant lung cancer via a nanogel …

WebNext, post-target resistance mechanisms preventing induction of apoptosis by cisplatin were studied in LTTs. The mRNA expression of the apoptotic regulators BCL-xL, BCL … WebApr 7, 2016 · Tubular cell apoptosis plays an essential pathogenic role for cisplatin-induced AKI. In this study, cell apoptosis was examined by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine nick-end labeling (TUNEL) staining and immuno-staining for cleaved caspase 3 in kidney tissues. greencroft bottling co ltd

Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in ...

WebJun 13, 2014 · In ovarian cancer cells that have developed acquired cisplatin resistance, both ERK activation and autophagy induction are increased. Importantly, knockdown of ERK or inhibition of autophagy promotes cisplatin-induced apoptosis in … WebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines We have assessed in detail the effect of cisplatin-activated programmed cell death in the cisplatin-sensitive human ovarian cancer cell line A2780 and two drug-resistant … WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in … greencroft bilston

(PDF) Induction of Apoptosis of Cancer Cells Using the Cisplatin ...

Acetyl-11-keto-β-boswellic acid enhances the cisplatin ... - PubMed

WebApoptosis inducers act on several apoptosis-related proteins to promote apoptotic cell death. Depending on the agent selected and the concentrations used, apoptotic events … WebCisplatin resistance is a daunting obstacle in cancer therapy and one of the major causes for treatment failure due to the inadequate drug activity and apoptosis induction. To overcome cisplatin resistance, we proposed a multifunctional nanogel (designated as Valproate-D-Nanogel) capable of reactivating cisplatin and enhancing early apoptosis. greencroft booksWebCisplatin helps in the treatment of various types of cancers in the body like such as ovarian, lung, head and neck, testicular and bladder. 5 Cisplatin is efficient in use against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. floyd county ymca summer camp

"WebThe manuscript by Bernardo-Bermejo analyses the metabolic differences between apoptotic bodies released by HK-2 cells, upon induction to apoptosis either by cisplatin or UV light. Although the topic may be potentially of interest, the manuscript is unclear, as well as the main findings. In addition, some methodological issues need to be addressed. " - Cisplatin apoptosis induction

Cisplatin apoptosis induction

Cisplatin-induced caspase activation mediates PTEN cleavage in …

WebNext, post-target resistance mechanisms preventing induction of apoptosis by cisplatin were studied in LTTs. The mRNA expression of the apoptotic regulators BCL-xL, BCL-xS, and BIRC5 /Survivin were elevated in all LTTs except 253J-LTT. BCL2 mRNA was slightly diminished in RT-112-LTT and 253J-LTT (Figure 4a, Figure S1d, Table S2). These … WebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell...

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WebAutophagy induction in cisplatin-treated cells was preceded by activation of adenosine monophosphate-activated protein kinase (AMPK) and concomitant down-regulation of mammalian target of rapamycin (mTOR)-mediated phosphorylation of p70S6 kinase. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …

WebCisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widel 掌桥科研一站式科研服务平台 Web1 day ago · Pomiferin suppresses apoptosis-resistant cells via induction of autophagy-dependent cell death. (A) ... Pomiferin potentiates the tumor suppression effect of cisplatin via attenuating ABCB1 activity and promoting cisplatin accumulation in tumor tissues of RM-1 drug-resistant prostate cancer bearing C57BL/6 mouse model. (A) ...

WebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts …

WebMay 10, 2013 · Chemotherapeutic drugs like cisplatin are known to act by inducing apoptosis. During apoptosis, a structurally related group of cysteine proteases known as caspases mediate protein cleavage [ 6, 7 ]. Caspases can be classified into two groups, more precisely initiator and effector caspases.

WebWe previously described that blocking ALDH activity enhances the induction of apoptosis, especially in ovarian cancer stem cells treated with chemotherapeutic agents. ... In combination with DSF and cisplatin, relatively more apoptosis and necrosis were induced in cisplatin-resistant cells than in their parental cells (apoptosis and necrosis ... floyd county water department jobsWebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis … greencroft bottling jobsWebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for treatment of human cancers. However, a major limitation of CDDP chemotherapy is serious drug resistance. greencroft bottling dh9 7xpWebWe have shown previously that β-elemene increases cisplatin cytotoxicity and enhances cisplatin sensitivity via blocking cell cycle progression at G2/M phase in resistant ovarian tumor cells. In the current study, we asked whether β-elemene-augmented cisplatin activity in ovarian carcinoma cells is mediated through the induction of apoptosis. greencroft board of directorsWebApr 28, 2011 · Furthermore, in agreement with a previous report, the apoptosis induced by cisplatin is dependent on the cell cycle. Indeed, cell death by apoptosis is significantly inhibited in nonproliferating cells (Fig. 5; ... Retinoid-related molecules require caspase 9 for the effective release of Smac and the rapid induction of apoptosis, ... floyd cove daylily facebookWebJun 1, 2007 · To investigate whether paeonol (Pae) has synergistic effects with cisplatin (CDDP) on the growth-inhibition and apoptosis-induction of human hepatoma cell lines HepG2 and SMMC-7721. Methods:... greencroft at homeWebAug 13, 2024 · Whereas hederagenin per se failed to cause any apoptosis, the combination of hederagenin and cisplatin significantly enhanced apoptotic cell death as compared … greencroft careers